ea0019p7 | Bone | SFEBES2009
Loh N
, Stechman M
, Ahmad B
, Hannan F
, Hough T
, Chiev K-P
, Stewart M
, Bentley L
, Cox R
, Brown S
, Thakker R
To identify genes causing hypercalciuria, we screened male offspring of C57BL/6J male mice mutagenised by N-ethyl-N-nitrosourea (ENU) for this abnormality. Mice were kept in accordance with UK Home Office welfare guidelines and project licence restrictions. Metabolic cage studies were performed to collect 24-hour urine samples, and this revealed one mouse with hypercalciuria (Hcalc1). Inheritance testing demonstrated that Hcalc1 was inherited as an autosomal domi...